Ethnobotanical Leaflets 11: 73-75. 2007.
Didymocarpus pedicellata: The Lithontriptic Ethnomedicine
Dr. Amrit Pal Singh
PGDMB; BAMS; MD (Alternative Medicine), Herbal Consultant, Ind-Swift Ltd, Chandigarh
Address for correspondence:
House No: 2101 Phase-7,
Issued 24 May 2007
Didymocarpus pedicellata R.Br. (Gesneriaceae) is valuable although a lesser known medicinal plant. It is popularly known as stone flower. In Ayurveda it is known as shilapushpa, shantapushpi and sometimes pasanbheda (Bahl &.Seshadri, 1978). In common language it is known as charela or patharphori.
Traditionally Didymocarpus pedicellata is used in the treatment of renal diseases particularly kidney stones (Kapoor & Kapoor, 1976). According to a hypothesis the plant is supposed to regulate calcium absorption in the body. The plant is known for its diuretic effect and in maintaining healthy urinary tract.
In Ayurveda pasanbheda is a drug of controversial origin. Further work on proper botanical identification of pasanbheda is warranted. The following plants are used as pasanbheda in different parts of India (Singh & Sandhu, 2005):
The plant is native to Tropical Asia (McGuffinet al).
Didymocarpus pedicellata is a small herb with a reduced stem, bearing 2-3 pairs of opposite, roundy ovate, glabrous, glandular-punctate leaves, 3-6 inches in diameter (Kapoor & Kapoor, 1976; Shah, Shah & Mody, 1972).
Chemically, the plant contains:
The essential oil of Didymocarpus pedicellata has antimicrobial activity (Singh, Sinha & Pathak, 1978).
Ethanolic extract of the aerial parts of Didymocarpus pedicellata demonstrated significant antioxidant and protective activity against ferric nitriloacetate induced renal oxidative stress, nephrotoxicity and tumor promotion response. Further the extract provided significant protection against. The extract also significantly and dose-dependently protected against ferric nitriloacetate mediated damage to lipids and DNA. The nephroprotective activity of the plant is attributed to polyphenolic compounds. The study further supported ancient use of plant in the treatment of kidney diseases (Kaur et al., 2007).
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2. Bahl, C.P. & T.R. Seshadri. Eds.1978. Pashanbhedi: drugs for urinary calculus, K.N. Udupa 77-98.
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4. Bose. P.C. & N. Chauadhary. 1978. Isodidmyocarpin, a new chalcone from Didymocarpus pedicellata. J Indian Chem 25:1198-1200.
5. Garg, S.K., Gupta, S.R. & N.D. Sharma. 1979. Synthesis of 7-hydroxy-5, 6, 8-trimethoxyflavone: revision of structure of didmyocarpin. Indian J Chem 17B:394-5.
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8. Kaur, G. et al. 2007. Protective effect of Didymocarpus pedicellata on ferric nitriloacetate induced renal oxidative stress and hyperproliferative response. Chem Biol Interact 165(1):33-34.
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10. Rao, K.V. et al. 1966. Isolation and constitution of pedicellic acid a new dicarboxylic acid from the leaves of Didymocarpus pedicellata. Tetrahedron 22(4):1495-98.
11. Rathore, J.S., Garg, S.K. & S.R. Gupta. 1981. A chalcone and flavanones from Didymocarpus pedicellata. Phytochem 20:1755-6.
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14. Sharma, V. & S. Siddiqui. 1939. The constituents of Didymocarpus pedicellata. Part 11. Comparative studies in the constitution of pedicin, isopedicin and pedicellin. J Indian Chem Soc 16:1-8.
15. Siddiqui, S. 1937. The constituents of Didymocarpus pedicellata. Part 1. Isolation of a new series of colouring matter. J Indian Chem Soc 12:703-8.
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17. Singh, P., Sinha, G.K. & RC. Pathak. 1978. Antimicrobial activity of some essential oils JRIM 13(4):111-114.